Therapeutic synergism between low-dose FK 506 and antimetabolites in rat allogeneic heart transplantation.

نویسندگان

  • M Tanabe
  • S Todo
  • N Murase
  • W Irish
  • H Miyazawa
  • S Fujisaki
  • T E Starzl
چکیده

FK 506 HAS HAD A major beneficial effect on the survival of transplanted organs. However. the use of FK 506 is limited by its toxicity. To circumvent this problem. we attempted to amplify the therapeutic efficacy of lowdose FK 506 bv the combined use of various antimetabolites, including' RS-61443 (RS),1 mizoribine (MIZ),2 and azathioprine (AZA). Therapeutic interaction was evaluated with rat allogeneic heart transplantation.

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عنوان ژورنال:
  • Transplantation proceedings

دوره 27 1  شماره 

صفحات  -

تاریخ انتشار 1995