Therapeutic synergism between low-dose FK 506 and antimetabolites in rat allogeneic heart transplantation.
نویسندگان
چکیده
FK 506 HAS HAD A major beneficial effect on the survival of transplanted organs. However. the use of FK 506 is limited by its toxicity. To circumvent this problem. we attempted to amplify the therapeutic efficacy of lowdose FK 506 bv the combined use of various antimetabolites, including' RS-61443 (RS),1 mizoribine (MIZ),2 and azathioprine (AZA). Therapeutic interaction was evaluated with rat allogeneic heart transplantation.
منابع مشابه
Combined immunosuppressive therapy with low dose FK506 and antimetabolites in rat allogeneic heart transplantation.
Following rat heterotopic heart allotransplantation, low to lethal doses of the antimetabolites mizoribine (MIZ), RS-61443 (RS), and AZA were given alone or in combination with subtherapeutic doses of FK506 (0.04 mg/kg/day) for 14 days after transplantation. With the median effect analysis of Chou and Kahan for quantitative drug interactions, substantial therapeutic synergism was demonstrated b...
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عنوان ژورنال:
- Transplantation proceedings
دوره 27 1 شماره
صفحات -
تاریخ انتشار 1995